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CD53 抗体

This anti-CD53 antibody is a 小鼠 单克隆 antibody detecting CD53 in FACS, IF 和 Func. Suitable for 人.
产品编号 ABIN6297690
发货至: 中国

Quick Overview for CD53 抗体 (ABIN6297690)

抗原

See all CD53 抗体
CD53

适用

  • 67
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宿主

  • 40
  • 29
小鼠

克隆类型

  • 42
  • 24
  • 3
单克隆

标记

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This CD53 antibody is un-conjugated

应用范围

  • 44
  • 33
  • 25
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  • 9
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Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)
  • 原理

    Mouse anti-Human CD53 Antibody [Sodium Azide Free]

    特异性

    Cell surface

    纯化方法

    Stimulated human leukocytes were used as the immunogen for the CD53 antibody.

    免疫原

    Stimulated human leukocytes were used as the immunogen for the CD53 antibody.
  • 应用备注

    Functional Activity (Order SAF formulation)
    Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
    Immunofluorescence: 0.5-1 μg/mL

    限制

    仅限研究用
  • 缓冲液

    In 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • 抗原

    CD53

    别名

    Leukocyte surface antigen CD53

    背景

    Target Description: Recognizes a protein of 33-55 kDa, identified as CD53 (Workshop VI, Code N-L033). It is expressed on monocytes and macrophages, dendritic cells, osteoblasts and osteoclasts, and on T and B cells from every stage of differentiation but is absent from platelets, red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. CD53 is a type III membrane with both termini in the cytoplasm and two loops in the extracellular environment. This molecule, in common with other members of tetraspan family, is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. CD53 crosslinking induces calcium flux on human monocyte and B cells. Cross-linking of CD53 promotes activation of resting human B-lymphocytes. This mAb recognizes CD53 transfected cells and partially inhibits T-cell proliferation induced by CD3 antibody (clone: UCHT1).

    Gene Symbol: CD53///MOX44///TSPAN25

    基因ID

    963

    UniProt

    P19397
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