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TSH receptor 抗体

This anti-TSH receptor antibody is a 小鼠 单克隆 antibody detecting TSH receptor in IHC, FACS 和 IF. Suitable for 人.
产品编号 ABIN6297584
发货至: 中国

Quick Overview for TSH receptor 抗体 (ABIN6297584)

抗原

See all TSH receptor (TSHR) 抗体
TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This TSH receptor antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
  • 原理

    Mouse anti-Human Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain) [Sodium Azide Free]

    特异性

    Cytoplasmic, cell surface

    纯化方法

    Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.

    免疫原

    Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.
  • 应用备注

    FACS: 0.5-1 μg/10^6 cells in 0.1ml
    IF: 1-2 μg/mL
    IHC (FFPE): 1-2 μg/mL for 30 min at RT

    限制

    仅限研究用
  • 缓冲液

    In 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • 抗原

    TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

    别名

    Thyrotropin receptor

    背景

    Target Description: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

    Gene Symbol: TSHR///LGR3

    基因ID

    7253

    UniProt

    P16473

    途径

    Thyroid Hormone Synthesis
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