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TSH receptor 抗体

TSHR 适用: 人 IHC, FACS, IF 宿主: 小鼠 Monoclonal unconjugated
产品编号 ABIN6297580
发货至: 中国
  • 抗原 See all TSH receptor (TSHR) 抗体
    TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
    适用
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    小鼠
    克隆类型
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    单克隆
    标记
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    This TSH receptor antibody is un-conjugated
    应用范围
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    Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
    原理
    Mouse anti-Human Thyroid Stimulating Hormone Receptor / TSHR Antibody (alpha chain) [Sodium Azide Free]
    特异性
    Cytoplasmic, cell surface
    纯化方法
    Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.
    免疫原
    Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.
    Top Product
    Discover our top product TSHR Primary Antibody
  • 应用备注
    FACS: 0.5-1 μg/10^6 cells in 0.1ml
    IF: 1-2 μg/mL
    IHC (FFPE): 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    In 1X PBS, BSA free, sodium azide free
    储存液
    Azide free
    储存条件
    4 °C,-20 °C
    储存方法
    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • 抗原
    TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
    别名
    Thyrotropin receptor (TSHR 产品)
    别名
    CHNG1 antibody, LGR3 antibody, hTSHR-I antibody, AI481368 antibody, hypothroid antibody, hyt antibody, pet antibody, TSHRA antibody, TSH-R antibody, thyroid stimulating hormone receptor antibody, tshr antibody, TSHR antibody, Tshr antibody
    背景

    Target Description: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

    Gene Symbol: TSHR///LGR3

    基因ID
    7253
    UniProt
    P16473
    途径
    Thyroid Hormone Synthesis
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