TYMS 抗体
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北京 101111
Quick Overview for TYMS 抗体 (ABIN6297577)
抗原
See all TYMS 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human Thymidylate Synthase Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
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免疫原
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
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anti-Thymidylate Synthetase (TYMS) (AA 36-313) antibody
TYMS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibodyTYMS 适用: 人 IF, WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3A1 unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibodyTYMS 适用: 人 IF, WB, FACS, IHC, ISt, RIA, StM 宿主: 小鼠 Monoclonal TYMS-1884 unconjugated
anti-Thymidylate Synthetase (TYMS) antibodyTYMS 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Thymidylate Synthetase (TYMS) antibodyTYMS 适用: 人 IF, WB, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymidylate Synthetase (TYMS) antibodyTYMS 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5H8 unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibodyTYMS 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 2B2 unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 265-294), (C-Term) antibodyTYMS 适用: 人 IF, WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20041 unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 2-54) antibodyTYMS 适用: 人 IF, WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 111-211) antibodyTYMS 适用: 人 WB, IHC, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 2B2 unconjugated
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应用备注
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FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- TYMS (Thymidylate Synthetase (TYMS))
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别名
- Thymidylate synthase
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背景
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Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Gene Symbol: TYMS///TS///OK///SW-cl.29
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基因ID
- 7298
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UniProt
- P04818
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途径
- Mitotic G1-G1/S Phases
抗原
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