CDKN1C 抗体
Quick Overview for CDKN1C 抗体 (ABIN6297439)
抗原
See all CDKN1C 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Mouse p57 Antibody [IHC only]
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特异性
- Nuclear
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纯化方法
- Recombinant human protein was used as the immunogen for the p57 antibody.
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免疫原
- Recombinant human protein was used as the immunogen for the p57 antibody.
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应用备注
- Prediluted format : incubate for 30 min at RT (2)
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限制
- 仅限研究用
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缓冲液
- Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))
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别名
- Cyclin-dependent kinase inhibitor 1C
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背景
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Target Description: Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
Gene Symbol: CDKN1C///KIP2
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基因ID
- 1028
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UniProt
- P49918
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途径
- Cell Division Cycle, Dopaminergic Neurogenesis
抗原
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