ALPL 抗体
Quick Overview for ALPL 抗体 (ABIN6297134)
抗原
See all ALPL 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Cow Alkaline Phosphatase Antibody (tissue-nonspecific) [Sodium Azide Free]
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特异性
- Cell surface, cytoplasmic, secreted
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纯化方法
- Recombinant human ALPL protein was used as the immunogen for the Alkaline Phosphatase antibody.
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免疫原
- Recombinant human ALPL protein was used as the immunogen for the Alkaline Phosphatase antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT
Prediluted format: incubate for 30 min at RT (1) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
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别名
- Alkaline phosphatase, tissue-nonspecific isozyme
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背景
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Target Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Gene Symbol: ALPL
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基因ID
- 249
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UniProt
- P05186
抗原
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