Transglutaminase 2 抗体
Quick Overview for Transglutaminase 2 抗体 (ABIN6297095)
抗原
See all Transglutaminase 2 (TGM2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- Mouse anti-Human/Monkey/Rabbit/Mouse/Rat TGM2 Antibody [Sodium Azide Free]
-
特异性
- Cytoplasmic and cell surface
-
纯化方法
- Recombinant full-length human protein was used as the immunogen for the TGM2 antibody.
-
免疫原
- Recombinant full-length human protein was used as the immunogen for the TGM2 antibody.
-
-
-
-
应用备注
-
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
-
-
-
缓冲液
- In 1X PBS, BSA free, sodium azide free
-
储存液
- Azide free
-
储存条件
- 4 °C,-20 °C
-
储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
-
-
- Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))
-
别名
- Protein-glutamine gamma-glutamyltransferase 2
-
背景
-
Target Description: Recognizes a 77-85 kDa protein, identified as cellular or tissue transglutaminase II (TGase II, TGM2). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Gene Symbol: TGM2
-
基因ID
- 7052
-
UniProt
- P21980
-
途径
- Tube Formation, Thromboxane A2 Receptor Signaling
抗原
-