Transgelin 抗体
Quick Overview for Transgelin 抗体 (ABIN6297094)
抗原
See all Transgelin (TAGLN) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Cow/Pig/Rabbit/Mouse SM22 alpha Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- Recombinant full-length human protein was used as the immunogen for the SM22 antibody.
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免疫原
- Recombinant full-length human protein was used as the immunogen for the SM22 antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Transgelin (TAGLN)
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别名
- Transgelin
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背景
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Target Description: This mAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Gene Symbol: TAGLN///SM22///WS3-10
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基因ID
- 6876
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UniProt
- Q01995
抗原
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