Glypican 3 抗体
Quick Overview for Glypican 3 抗体 (ABIN6296942)
抗原
See all Glypican 3 (GPC3) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Rat Glypican-3 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- Recombinant full-length human GPC3 protein was used as the immunogen for the Glypican-3 antibody.
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免疫原
- Recombinant full-length human GPC3 protein was used as the immunogen for the Glypican-3 antibody.
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anti-Glypican 3 (GPC3) antibody
GPC3 适用: 人, 大鼠, 小鼠 FACS, WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 9C2 unconjugated
anti-Glypican 3 (GPC3) (AA 344-559) antibodyGPC3 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Glypican 3 (GPC3) antibodyGPC3 适用: 人, 大鼠 IF, FACS, IHC, StM 宿主: 小鼠 Monoclonal GPC3-863 unconjugated
anti-Glypican 3 (GPC3) (AA 55-200) antibodyGPC3 适用: 人 IF, FACS, WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 9C2 unconjugated
anti-Glypican 3 (GPC3) (AA 359-554) antibodyGPC3 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 2C7E9 unconjugated
anti-Glypican 3 (GPC3) (AA 55-200) antibodyGPC3 适用: 人, 小鼠 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 2A2C3 unconjugated
anti-Glypican 3 (GPC3) antibodyGPC3 适用: 人, 大鼠 IF, FACS, IHC, StM 宿主: 小鼠 Monoclonal rGPC3-863 unconjugated Recombinant Antibody
anti-Glypican 3 (GPC3) (AA 511-580) antibodyGPC3 适用: 人 IF, FACS, WB, IHC, StM 宿主: 小鼠 Monoclonal 1G12 unconjugated
anti-Glypican 3 (GPC3) (AA 359-554) antibodyGPC3 适用: 人, 大鼠 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 4D5B1 unconjugated
anti-Glypican 3 (GPC3) antibodyGPC3 适用: 人, 小鼠 IF, WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 9C2 unconjugated
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Glypican 3 (GPC3)
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别名
- Glypican-3
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背景
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Target Description: Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100 % in follicular carcinoma and 70 % in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
Gene Symbol: GPC3///OCI5
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基因ID
- 2719
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UniProt
- P51654
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途径
- Glycosaminoglycan Metabolic Process
抗原
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