Fascin 抗体
Quick Overview for Fascin 抗体 (ABIN6296304)
抗原
See all Fascin (FSCN1) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Rat Fascin Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- Full length recombinant human protein was used as the immunogen for the Fascin antibody.
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免疫原
- Full length recombinant human protein was used as the immunogen for the Fascin antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistology (FFPE): 0.5-1.0 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Fascin (FSCN1)
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别名
- Fascin
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背景
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Target Description: Fascin/FSCN1 binds beta-catenin and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of FSCN1 in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. It localizes to actin-rich protrusions at the cell surface called filopodia. FSCN1 localizes to invadopodia, membrane protrusions formed at the adherent cell surface that facilitate extracellular matrix (ECM) invasion, this provide a potential molecular mechanism for how fascin increases the invasiveness of cancer cells since fascin expression is upregulated in a spectrum of cancers. [Wiki]
Gene Symbol: FSCN1///FAN1///HSN///SNL
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基因ID
- 6624
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UniProt
- Q16658
抗原
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