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FOXA1 抗体

The 小鼠 单克隆 anti-FOXA1 antibody (ABIN6296010) specifically detects FOXA1 in WB, IHC, IF 和 FACS. The antibody is reactive with 人 和 大鼠 samples.
产品编号 ABIN6296010
发货至: 中国
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Quick Overview for FOXA1 抗体 (ABIN6296010)

抗原

See all FOXA1 抗体
FOXA1 (Forkhead Box A1 (FOXA1))

适用

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人, 大鼠

宿主

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  • 88
  • 1
小鼠

克隆类型

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  • 56
单克隆

标记

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This FOXA1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
  • 原理

    Mouse anti-Human/Rat FOXA1 Antibody [Sodium Azide Free]

    特异性

    Nuclear

    纯化方法

    A human recombinant partial protein corresponding to amin acids 372-472 was used as the immunogen for this FOXA1 antibody.

    免疫原

    A human recombinant partial protein corresponding to amin acids 372-472 was used as the immunogen for this FOXA1 antibody.
  • 应用备注

    FACS: 0.5-1 μg/10^6 cells
    IF: 0.5-1 μg/mL
    WB: 0.5-1 μg/mL
    IHC (FFPE): 0.5-1 μg/mL for 30 min at RT

    限制

    仅限研究用
  • 缓冲液

    In 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • 抗原

    FOXA1 (Forkhead Box A1 (FOXA1))

    别名

    Hepatocyte nuclear factor 3-alpha

    背景

    Target Description: The transcription factor Forkhead-box A1, also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. Its expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

    Gene Symbol: FOXA1///HNF3A///TCF3A

    基因ID

    3169

    UniProt

    P55317

    途径

    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis
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