MAML3 抗体
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Quick Overview for MAML3 抗体 (ABIN6295979)
抗原
See all MAML3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human MAML3 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- A human full length recombinant protein was used as the immunogen for this MAML3 antibody.
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免疫原
- A human full length recombinant protein was used as the immunogen for this MAML3 antibody.
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anti-Mastermind-Like 3 (MAML3) antibody
MAML3 适用: 人 ISt, IHC, StM 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 1024-1131) antibodyMAML3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 640-665), (C-Term) antibodyMAML3 适用: 人 FACS, WB, IHC (p) 宿主: 兔 Polyclonal RB18761 unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 791-840) antibodyMAML3 适用: 人, 小鼠, 马, 兔, 犬, 豚鼠, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 DB 宿主: 小鼠 Monoclonal 797C2a unconjugated
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应用备注
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FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL (1) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- MAML3 (Mastermind-Like 3 (MAML3))
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别名
- Mastermind-like protein 3
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背景
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Target Description: Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.
Gene Symbol: MAML3///KIAA1816
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基因ID
- 55534
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UniProt
- Q96JK9
抗原
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