KRT17 抗体
Quick Overview for KRT17 抗体 (ABIN6295932)
抗原
See all KRT17 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Rat/Cow/Goat/Pig Cytokeratin 17 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- A cytoskeletal fraction of rat colon epithelium was used as the immunogen for this Cytokeratin 17 antibody.
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免疫原
- A cytoskeletal fraction of rat colon epithelium was used as the immunogen for this Cytokeratin 17 antibody.
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anti-Keratin 17 (KRT17) antibody
KRT17 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Keratin 17 (KRT17) (AA 252-393) antibodyKRT17 适用: 人 WB, IHC, FACS, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Keratin 17 (KRT17) (AA 1-432) antibodyKRT17 适用: 人 WB, IF, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 2D4-1G9 unconjugated
anti-Keratin 17 (KRT17) antibodyKRT17 适用: 人, 大鼠 WB, IHC, FACS, ICC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal E3 unconjugated
anti-Keratin 17 (KRT17) (AA 133-432) antibodyKRT17 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Keratin 17 (KRT17) antibodyKRT17 适用: 人, 大鼠, Cow, Pig, 山羊 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal SPM560 unconjugated
anti-Keratin 17 (KRT17) antibodyKRT17 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Keratin 17 (KRT17) (C-Term) antibodyKRT17 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Keratin 17 (KRT17) antibodyKRT17 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-Keratin 17 (KRT17) (C-Term) antibodyKRT17 适用: 人, 大鼠, 小鼠, Cow, Pig, 犬, 兔, 绵羊, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Western blot: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- KRT17 (Keratin 17 (KRT17))
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别名
- Keratin, type I cytoskeletal 17
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背景
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Target Description: Cytokeratin 17 (CK17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IF's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. CK17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered an epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. CK17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20 % of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
Gene Symbol: KRT17
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基因ID
- 3872
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UniProt
- Q04695
抗原
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