Chromogranin A 抗体
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Quick Overview for Chromogranin A 抗体 (ABIN6295897)
抗原
See all Chromogranin A (CHGA) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Monkey/Pig/Mouse/Rat Chromogranin A Antibody Cocktail [Sodium Azide Free]
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特异性
- Finely granular cytoplasmic
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纯化方法
- Human pheochromocytoma cells (LK2H10 + PHE5) and recombinant human Chromogranin A protein (CGA414) were used as the immunogen for this antibody.
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免疫原
- Human pheochromocytoma cells (LK2H10 + PHE5) and recombinant human Chromogranin A protein (CGA414) were used as the immunogen for this antibody.
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应用备注
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FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Chromogranin A (CHGA)
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别名
- Chromogranin-A , AL-11, GV-19, GR-44, ER-37, GE-25, Serpinin-RRG, Serpinin, p-Glu serpinin precursor]
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背景
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Target Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
Gene Symbol: CHGA
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基因ID
- 1113
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UniProt
- P10645
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途径
- Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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