PAX6 抗体 (N-Term)
Quick Overview for PAX6 抗体 (N-Term) (ABIN6295578)
抗原
See all PAX6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-300, N-Term
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原理
- Mouse anti-Human PAX-6 Antibody [Sodium Azide Free]
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特异性
- Nuclear
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纯化方法
- A recombinant fragment (N-terminus, aa 1-300) was used as the immunogen for the PAX-6 antibody.
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免疫原
- A recombinant fragment (N-terminus, aa 1-300) was used as the immunogen for the PAX-6 antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- PAX6 (Paired Box 6 (PAX6))
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别名
- Paired box protein Pax-6
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背景
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Target Description: Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
Gene Symbol: PAX6///AN2
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基因ID
- 5080
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UniProt
- P26367
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途径
- Peptide Hormone Metabolism, Carbohydrate Homeostasis
抗原
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