ALPL 抗体 (Center)
Quick Overview for ALPL 抗体 (Center) (ABIN6295240)
抗原
See all ALPL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 217-246, Center
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原理
- Rabbit Anti-ALPL (Center) Antibody
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免疫原
- This ALPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the Central region of human ALPL.
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
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别名
- ALPL
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背景
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Target Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The genes for the first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. This protein is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
Gene Symbol: ALPL
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基因ID
- 249
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UniProt
- P05186
抗原
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