KRT6A 抗体 (C-Term)
Quick Overview for KRT6A 抗体 (C-Term) (ABIN6294644)
抗原
See all KRT6A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Mouse anti-Human/Mouse Cytokeratin 6 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from the C-terminus of human Cytokeratin 6 was used as the immunogen for this antibody.
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免疫原
- A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from the C-terminus of human Cytokeratin 6 was used as the immunogen for this antibody.
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应用备注
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FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
IHC (FFPE): 0.5-1.0 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- KRT6A (Keratin 6A (KRT6A))
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别名
- Keratin, type II cytoskeletal 6A
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背景
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Target Description: This antibody recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6) or Keratin 6. In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express Cytokeratin 6 and 16. Keratin 6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of Cytokeratin 6 is particularly associated with differentiation.
Gene Symbol: KRT6A///K6A///KRT6D
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基因ID
- 3853
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UniProt
- P02538
抗原
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