Filaggrin 抗体 (AA 998-1104)
Quick Overview for Filaggrin 抗体 (AA 998-1104) (ABIN6294618)
抗原
See all Filaggrin (FLG) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 998-1104
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原理
- Mouse anti-Human Filaggrin Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic
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纯化方法
- Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody.
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免疫原
- Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody.
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应用备注
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FACS: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 min at RT -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Filaggrin (FLG)
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别名
- Filaggrin
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背景
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Target Description: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Gene Symbol: FLG
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基因ID
- 2312
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UniProt
- P20930
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途径
- Sensory Perception of Sound, Stem Cell Maintenance
抗原
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