ANO1 抗体 (AA 904-986)
Quick Overview for ANO1 抗体 (AA 904-986) (ABIN6294609)
抗原
See all ANO1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 904-986
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原理
- Mouse anti-Human DOG-1 Antibody [Sodium Azide Free]
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特异性
- Cell Surface and Cytoplasm
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纯化方法
- Amino acids 904-986 from the human protein was used as the immunogen for this DOG-1 antibody.
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免疫原
- Amino acids 904-986 from the human protein was used as the immunogen for this DOG-1 antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.25-0.5 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
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别名
- Anoctamin-1
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背景
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Target Description: Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4 % vs. 94.7 %.
Gene Symbol: ANO1///DOG1///ORAOV2///TAOS2///TMEM16A
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基因ID
- 55107
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UniProt
- Q5XXA6
抗原
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