FOXA1 抗体 (AA 372-472)
Quick Overview for FOXA1 抗体 (AA 372-472) (ABIN6294499)
抗原
See all FOXA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 372-472
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原理
- Mouse anti-Human/Rat FOXA1 Antibody [Sodium Azide Free]
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特异性
- Nuclear
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纯化方法
- A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.
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免疫原
- A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.
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应用备注
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FACS: 0.5-1 μg/10^6 cells
IF: 0.5-1 μg/mL
IHC (FFPE): 1-2 μg/mL for 30 min at RT -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- FOXA1 (Forkhead Box A1 (FOXA1))
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别名
- Hepatocyte nuclear factor 3-alpha
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背景
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Target Description: The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.
Gene Symbol: FOXA1///HNF3A///TCF3A
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基因ID
- 3169
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UniProt
- P55317
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis
抗原
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