TEAD2 抗体 (Center)
Quick Overview for TEAD2 抗体 (Center) (ABIN6294438)
抗原
See all TEAD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 267-295, Center
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原理
- Rabbit Anti-TEAD2 (Center) Antibody
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免疫原
- This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the Central region of human TEAD2.
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- TEAD2 (TEA Domain Family Member 2 (TEAD2))
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别名
- TEAD2
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背景
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Target Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Gene Symbol: TEAD2
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基因ID
- 8463
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UniProt
- Q15562
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途径
- Regulation of Lipid Metabolism by PPARalpha, Tube Formation
抗原
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