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BCL6 抗体 (AA 256-389)

This anti-BCL6 antibody is a 小鼠 单克隆 antibody detecting BCL6 in IHC, FACS 和 IF. Suitable for 人.
产品编号 ABIN6294426
发货至: 中国

Quick Overview for BCL6 抗体 (AA 256-389) (ABIN6294426)

抗原

See all BCL6 抗体
BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This BCL6 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
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    AA 256-389

    原理

    Mouse anti-Human Bcl6 Antibody [Sodium Azide Free]

    特异性

    Nuclear

    纯化方法

    Amino acids 256-389 from the human protein were used as the immunogen for the Bcl6 antibody.

    免疫原

    Amino acids 256-389 from the human protein were used as the immunogen for the Bcl6 antibody.
  • 应用备注

    Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
    Immunofluorescence: 1-2 μg/mL
    IHC (FFPE): 1-2 μg/mL for 30 min at RT

    限制

    仅限研究用
  • 缓冲液

    In 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • 抗原

    BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

    别名

    B-cell lymphoma 6 protein

    背景

    Target Description: Antibody to Bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show Bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, Bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

    Gene Symbol: BCL6///BCL5///LAZ3///ZBTB27///ZNF51

    基因ID

    604

    UniProt

    P41182

    途径

    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
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