Leptin Receptor 抗体 (C-Term)
Quick Overview for Leptin Receptor 抗体 (C-Term) (ABIN6266243)
抗原
See all Leptin Receptor (LEPR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Leptin Receptor Antibody detects endogenous levels of total Leptin Receptor.
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预测反应
- Pig,Rabbit,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human Leptin Receptor, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Leptin Receptor (LEPR) (AA 901-1000) antibody
LEPR 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, FACS, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leptin Receptor (LEPR) (AA 310-539) antibodyLEPR 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leptin Receptor (LEPR) (AA 22-203) antibodyLEPR 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leptin Receptor (LEPR) (AA 238-375) antibodyLEPR 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Leptin Receptor (LEPR) (Internal Region) antibodyVerified LEPR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Leptin Receptor (LEPR) antibodyLEPR 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Leptin Receptor (LEPR) (AA 23-52) antibodyLEPR 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Leptin Receptor (LEPR) (AA 501-600) antibodyLEPR 适用: 人, 小鼠, 大鼠 WB, FACS, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leptin Receptor (LEPR) (AA 31-130) antibodyLEPR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-Leptin Receptor (LEPR) (AA 23-52), (N-Term) antibodyLEPR 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB02053 unconjugated
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应用备注
- WB 1:500-1:1000, IHC 1:50-1:100, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Leptin Receptor (LEPR)
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别名
- LEPR
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背景
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Description: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
Gene: LEPR
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分子量
- 96kDa
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基因ID
- 3953
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UniProt
- P48357
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途径
- JAK/STAT Signaling, AMPK Signaling, Feeding Behaviour
抗原
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