TJP1 抗体
(2 references)Quick Overview for TJP1 抗体 (ABIN6266146)
抗原
See all TJP1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- ZO 1 Antibody detects endogenous levels of total ZO 1
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交叉反应
- 人, 小鼠, 猪, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ZO 1
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亚型
- IgG
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anti-Tight Junction Protein 1 (TJP1) (AA 1551-1702) antibody
TJP1 适用: 人, 小鼠, 大鼠, Pig, Cow WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) (C-Term) antibodyTJP1 适用: 人, 小鼠, 大鼠, Pig, Cow, 犬, 豚鼠, 兔, 马, 猴, 小鸡, Avian, Cat, 驴, 山羊, Hamster, 绵羊 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) (N-Term) antibodyKO Validated TJP1 适用: 人 WB, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) (Internal Region) antibodyVerified TJP1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) (AA 1600-1700) antibodyTJP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) antibodyTJP1 适用: 人 WB, IHC, ELISA, IF, FACS, FM, MA 宿主: 兔 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) antibodyTJP1 适用: 人 WB, IHC, ELISA, IF, FACS, FM, MA 宿主: 兔 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) (AA 1178-1527) antibodyTJP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) antibodyTJP1 适用: 小鼠 WB, IHC, IP 宿主: 大鼠 Monoclonal unconjugated
anti-Tight Junction Protein 1 (TJP1) (AA 1-190) antibodyTJP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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: "Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7." in: International immunopharmacology, Vol. 58, pp. 64-71, (2018) (PubMed).
: "Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model." in: BioMed research international, Vol. 2016, pp. 5436738, (2017) (PubMed).
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: "Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7." in: International immunopharmacology, Vol. 58, pp. 64-71, (2018) (PubMed).
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- TJP1 (Tight Junction Protein 1 (TJP1))
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别名
- ZO 1
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背景
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Description: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).
Gene: TJP1
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分子量
- 195 kDa
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基因ID
- 7082
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UniProt
- Q07157
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途径
- Carbohydrate Homeostasis, Cell-Cell Junction Organization
抗原
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