YME1L1 抗体 (C-Term)
Quick Overview for YME1L1 抗体 (C-Term) (ABIN6266079)
抗原
See all YME1L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- YME1L1 Antibody detects endogenous levels of total YME1L1.
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预测反应
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human YME1L1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-YME1-Like 1 (YME1L1) (AA 1-240) antibody
YME1L1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-YME1-Like 1 (YME1L1) (AA 191-219), (N-Term) antibodyYME1L1 适用: 人, Hamster WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24746 unconjugated
anti-YME1-Like 1 (YME1L1) (AA 1-240) antibodyYME1L1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- YME1L1 (YME1-Like 1 (YME1L1))
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别名
- YME1L1
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背景
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Description: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461).
Gene: YME1L1
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分子量
- 86 kDa
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基因ID
- 10730
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UniProt
- Q96TA2
抗原
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