WNK2 抗体 (Internal Region)
Quick Overview for WNK2 抗体 (Internal Region) (ABIN6266033)
抗原
See all WNK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- WNK2 Antibody detects endogenous levels of total WNK2.
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预测反应
- Pig,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human WNK2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) (AA 1177-1464) antibody
WNK2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) (AA 2118-2217) antibodyWNK2 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 2E10 unconjugated
anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) antibodyWNK2 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 2 (WNK2) (AA 2118-2217) antibodyWNK2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2A2 unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))
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别名
- WNK2
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背景
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Description: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Gene: WNK2
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分子量
- 243ka
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基因ID
- 65268
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UniProt
- Q9Y3S1
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途径
- Photoperiodism
抗原
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