USP36 抗体
Quick Overview for USP36 抗体 (ABIN6265926)
抗原
See all USP36 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- USP36 Antibody detects endogenous levels of total USP36
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交叉反应
- 人, 小鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human USP36
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 36 (USP36) (AA 589-972) antibody
USP36 适用: 人, 犬 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 7G3 unconjugated
anti-Ubiquitin Specific Peptidase 36 (USP36) (AA 670-881) antibodyUSP36 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 36 (USP36) (AA 71-120) antibodyUSP36 适用: 人, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 36 (USP36) (AA 1-120) antibodyUSP36 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 36 (USP36) (N-Term) antibodyUSP36 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000 IHC 1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- USP36 (Ubiquitin Specific Peptidase 36 (USP36))
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别名
- USP36
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背景
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Description: Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).
Gene: USP36
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分子量
- 125kDa
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基因ID
- 57602
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UniProt
- Q9P275
抗原
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