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- 抗原 See all USP10 抗体
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This USP10 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- USP10 Antibody detects endogenous levels of total USP10.
- 预测反应
- Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human USP10, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product USP10 Primary Antibody
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anti-Ubiquitin Specific Peptidase 10 (USP10) antibody
USP10 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1A10 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人, 猴 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1H9 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 1-798) antibodyUSP10 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 699-797) antibodyUSP10 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 1-798) antibodyUSP10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 301-350) antibodyUSP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 487-536) antibodyUSP10 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 非洲爪蟾, Bat, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 499-798) antibodyUSP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
- 别名
- USP10 (USP10 产品)
- 别名
- T4F9.30 antibody, T4F9_30 antibody, ubiquitin-specific protease 9 antibody, ubpo antibody, USP10 antibody, id:ibd1190 antibody, wu:fc19h08 antibody, wu:fc76g05 antibody, wu:fi11g01 antibody, UBPO antibody, 2610014N07Rik antibody, Uchrp antibody, mKIAA0190 antibody, usp10-A antibody, ubiquitin specific peptidase 10 antibody, universal stress protein UspA antibody, ubiquitin-specific protease 9 antibody, ubiquitin carboxyl-terminal hydrolase 10 antibody, ubiquitin specific peptidase 10 S homeolog antibody, USP10 antibody, RR_RS14970 antibody, UBP9 antibody, PTRG_07201 antibody, MGYG_06403 antibody, usp10 antibody, Usp10 antibody, usp10.S antibody
- 背景
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Description: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).
Gene: USP10
- 分子量
- 87 kDa
- 基因ID
- 9100
- UniProt
- Q14694
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