USP10 抗体 (N-Term)
Quick Overview for USP10 抗体 (N-Term) (ABIN6265909)
抗原
See all USP10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- USP10 Antibody detects endogenous levels of total USP10.
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预测反应
- Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human USP10, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 10 (USP10) antibody
USP10 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人, 猴 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1H9 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1A10 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 1-798) antibodyUSP10 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 699-797) antibodyUSP10 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 1-798) antibodyUSP10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) antibodyUSP10 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 487-536) antibodyUSP10 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 301-350) antibodyUSP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 499-798) antibodyUSP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
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别名
- USP10
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背景
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Description: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).
Gene: USP10
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分子量
- 87 kDa
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基因ID
- 9100
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UniProt
- Q14694
抗原
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