UBR2 抗体 (C-Term)
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Quick Overview for UBR2 抗体 (C-Term) (ABIN6265862)
抗原
See all UBR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- UBR2 Antibody detects endogenous levels of total UBR2.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human UBR2, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (AA 1-100) antibody
UBR2 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 4G4 unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (AA 101-439) antibodyUBR2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) antibodyUBR2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (Internal Region) antibodyVerified UBR2 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (AA 1-100) antibodyUBR2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (AA 1-439) antibodyUBR2 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (C-Term) antibodyUBR2 适用: 人, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (C-Term) antibodyUBR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (C-Term) antibodyUBR2 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 兔, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))
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别名
- UBR2
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背景
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Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retranstoposon mobilization (By similarity).
Gene: UBR2
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分子量
- 201kDa
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基因ID
- 23304
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UniProt
- Q8IWV8
抗原
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