TXK 抗体 (N-Term)
Quick Overview for TXK 抗体 (N-Term) (ABIN6265813)
抗原
See all TXK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- TXK Antibody detects endogenous levels of total TXK.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human TXK, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-TXK tyrosine Kinase (TXK) (AA 32-83) antibody
TXK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TXK tyrosine Kinase (TXK) (C-Term) antibodyVerified TXK 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-TXK tyrosine Kinase (TXK) (AA 131-230) antibodyTXK 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D8 unconjugated
anti-TXK tyrosine Kinase (TXK) (AA 286-509) antibodyTXK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TXK tyrosine Kinase (TXK) (AA 22-52), (N-Term) antibodyTXK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB03245 unconjugated
anti-TXK tyrosine Kinase (TXK) antibodyTXK 适用: 人 WB 宿主: 小鼠 Monoclonal F35 P7 D7 F5 unconjugated
anti-TXK tyrosine Kinase (TXK) (AA 1-180) antibodyTXK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TXK tyrosine Kinase (TXK) antibodyTXK 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TXK tyrosine Kinase (TXK) (N-Term) antibodyTXK 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- TXK (TXK tyrosine Kinase (TXK))
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别名
- TXK
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背景
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Description: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
Gene: TXK
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分子量
- 61 kDa
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基因ID
- 7294
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UniProt
- P42681
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途径
- Regulation of Leukocyte Mediated Immunity, Hepatitis C
抗原
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