TRIM21 抗体 (C-Term)
Quick Overview for TRIM21 抗体 (C-Term) (ABIN6265729)
抗原
See all TRIM21 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- TRIM21 Antibody detects endogenous levels of total TRIM21.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human TRIM21, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Tripartite Motif Containing 21 (TRIM21) (AA 80-330) antibody
TRIM21 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (C-Term) antibodyVerified TRIM21 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) antibodyTRIM21 适用: 人 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (AA 301-400) antibodyTRIM21 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (AA 268-465) antibodyTRIM21 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibodyTRIM21 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2C9 unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibodyTRIM21 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibodyTRIM21 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (AA 68-175) antibodyTRIM21 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibodyTRIM21 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- TRIM21 (Tripartite Motif Containing 21 (TRIM21))
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别名
- TRIM21
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背景
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Description: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).
Gene: TRIM21
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分子量
- 54kDa
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基因ID
- 6737
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UniProt
- P19474
抗原
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