TNK2 抗体 (C-Term)
Quick Overview for TNK2 抗体 (C-Term) (ABIN6265655)
抗原
See all TNK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- ACK1 Antibody detects endogenous levels of total ACK1.
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预测反应
- Pig,Bovine,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ACK1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 1-352) antibody
TNK2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr284) antibodyTNK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 10-39), (N-Term) antibodyTNK2 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB15601 unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 21-120) antibodyTNK2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr857), (pTyr858) antibodyTNK2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr284) antibodyTNK2 适用: 人, 小鼠, 大鼠, Cow, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 250-299), (pTyr284) antibodyTNK2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 301-420) antibodyTNK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 1-352) antibodyTNK2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (Tyr530) antibodyTNK2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))
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别名
- TNK2
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背景
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Description: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370).
Gene: TNK2
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分子量
- 114kDa
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基因ID
- 10188
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UniProt
- Q07912
抗原
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