ZFP36L1 抗体 (Internal Region)
Quick Overview for ZFP36L1 抗体 (Internal Region) (ABIN6265589)
抗原
See all ZFP36L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- TIS11B Antibody detects endogenous levels of total TIS11B.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human TIS11B, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 1-108) antibody
ZFP36L1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (Middle Region) antibodyZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 64-93), (N-Term) antibodyZFP36L1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40956 unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 66-115) antibodyZFP36L1 适用: 人, 犬, Cow, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 46-95) antibodyZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (N-Term) antibodyZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 1-108) antibodyZFP36L1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (C-Term) antibodyZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (Ser189) antibodyZFP36L1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 46-95) antibodyZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- ZFP36L1 (ZFP36 Ring Finger Protein-Like 1 (ZFP36L1))
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别名
- ZFP36L1
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背景
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Description: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing, modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).
Gene: ZFP36L1
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分子量
- 36kDa
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基因ID
- 677
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UniProt
- Q07352
抗原
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