THRAP3 抗体 (N-Term)
Quick Overview for THRAP3 抗体 (N-Term) (ABIN6265560)
抗原
See all THRAP3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- THRAP3 Antibody detects endogenous levels of total THRAP3.
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预测反应
- Bovine,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human THRAP3, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Thyroid Hormone Receptor Associated Protein 3 (THRAP3) (AA 631-730) antibody
THRAP3 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Associated Protein 3 (THRAP3) (C-Term) antibodyTHRAP3 适用: 人 IHC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Associated Protein 3 (THRAP3) (C-Term) antibodyTHRAP3 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 兔, 非洲爪蟾, 马, 猴, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Associated Protein 3 (THRAP3) (Middle Region) antibodyTHRAP3 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 兔, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Associated Protein 3 (THRAP3) (AA 927-955), (C-Term) antibodyTHRAP3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- THRAP3 (Thyroid Hormone Receptor Associated Protein 3 (THRAP3))
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别名
- THRAP3
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背景
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Description: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition, the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex, however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Gene: THRAP3
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分子量
- 109kDa
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基因ID
- 9967
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UniProt
- Q9Y2W1
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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