SOCS3 抗体 (C-Term)
Quick Overview for SOCS3 抗体 (C-Term) (ABIN6265217)
抗原
See all SOCS3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- SOCS3 Antibody detects endogenous levels of total SOCS3.
-
预测反应
- Bovine,Horse,Sheep,Dog,Chicken
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human SOCS3, corresponding to a region within C-terminal amino acids.
-
亚型
- IgG
-
-
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (C-Term) antibody
SOCS3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) antibodySOCS3 适用: 人 ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 155-225) antibodySOCS3 适用: 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-224) antibodySOCS3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-226) antibodySOCS3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) antibodySOCS3 适用: 人 WB 宿主: 小鼠 Monoclonal SO1 unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (C-Term) antibodySOCS3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 71-85), (Middle Region) antibodySOCS3 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) antibodySOCS3 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) antibodySOCS3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
-
别名
- SOCS3
-
背景
-
Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Gene: SOCS3
-
分子量
- 25kDa
-
基因ID
- 9021
-
UniProt
- O14543
-
途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
抗原
-
