SNAPIN 抗体 (N-Term)
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北京 101111
Quick Overview for SNAPIN 抗体 (N-Term) (ABIN6265206)
抗原
See all SNAPIN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- SNAPIN Antibody detects endogenous levels of total SNAPIN.
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预测反应
- Pig,Bovine,Horse,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human SNAPIN, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-SNAP-Associated Protein (SNAPIN) (AA 1-136) antibody
SNAPIN 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SNAP-Associated Protein (SNAPIN) (AA 41-137) antibodySNAPIN 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H1 unconjugated
anti-SNAP-Associated Protein (SNAPIN) (AA 41-136) antibodySNAPIN 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H1 unconjugated
anti-SNAP-Associated Protein (SNAPIN) (AA 2-136) antibodySNAPIN 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-SNAP-Associated Protein (SNAPIN) (AA 41-136) antibodySNAPIN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SNAP-Associated Protein (SNAPIN) (AA 1-136) antibodySNAPIN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SNAP-Associated Protein (SNAPIN) (AA 117-136) antibodySNAPIN 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- SNAPIN (SNAP-Associated Protein (SNAPIN))
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别名
- SNAPIN
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背景
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Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).
Gene: SNAPIN
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分子量
- 15-18 kDa
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基因ID
- 23557
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UniProt
- O95295
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途径
- Synaptic Membrane, Synaptic Vesicle Exocytosis
抗原
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