SGTA 抗体 (C-Term)
Quick Overview for SGTA 抗体 (C-Term) (ABIN6265046)
抗原
See all SGTA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- SGTA Antibody detects endogenous levels of total SGTA.
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预测反应
- Pig,Zebrafish,Bovine,Sheep,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human SGTA, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (AA 42-123) antibody
SGTA 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 2E11 unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (AA 1-313) antibodySGTA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (AA 1-313) antibodySGTA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (AA 1-120) antibodySGTA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (Center) antibodySGTA 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (AA 1-120) antibodySGTA 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (AA 84-97) antibodyVerified SGTA 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) antibodySGTA 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) antibodySGTA 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA))
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别名
- SGTA
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背景
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Description: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
Gene: SGTA
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分子量
- 34-37 kDa
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基因ID
- 6449
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UniProt
- O43765
抗原
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