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RUNX3 抗体 (Internal Region)

There is 1 publication for this product available. The 兔多克隆 anti-RUNX3 antibody is suitable to detect RUNX3 in samples from 人和小鼠. It has been validated for WB, ELISA, IHC, IF 和 ICC.

IF/ICC

2 images

(1 reference)

产品编号 ABIN6264885

发货至: 中国

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Quick Overview for RUNX3 抗体 (Internal Region) (ABIN6264885)

抗原

See all RUNX3 抗体

RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This RUNX3 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product RUNX3 Primary Antibody

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Internal Region

特异性

RUNX3 Antibody detects endogenous levels of total RUNX3.

预测反应

Pig,Bovine,Horse,Rabbit,Dog,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human RUNX3, corresponding to a region within the internal amino acids.

亚型

IgG
anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 31-130) antibody
RUNX3 适用: 人 WB, ELISA, IF (p), FACS, IF (cc), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 1-429) antibody
RUNX3 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 294-429) antibody
RUNX3 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 7E2B8 unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 128-270) antibody
RUNX3 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 186-252) antibody
RUNX3 适用: 人, 小鼠 WB, ELISA, IHC, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 1-429) antibody
RUNX3 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 168-197) antibody
RUNX3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 1-415) antibody
RUNX3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 194-279) antibody
RUNX3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 3 (RUNX3) (AA 294-429) antibody
RUNX3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 8C9B6 unconjugated

应用备注

WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Li, Zhao, Huang, Wang, Zhu, Cao, Xiong, Deng: "MiR-93-5p promotes gastric cancer-cell progression via inactivation of the Hippo signaling pathway." in: Gene, Vol. 641, pp. 240-247, (2017) (PubMed).
抗原

RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

别名

RUNX3

背景

Description: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
Gene: RUNX3

分子量

44 kDa

基因ID

864

UniProt

Q13761