RFX3 抗体 (C-Term)
Quick Overview for RFX3 抗体 (C-Term) (ABIN6264716)
抗原
See all RFX3 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- C-Term
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                                            特异性
- RFX3 Antibody detects endogenous levels of total RFX3.
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                                            预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
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                                            纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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                                            免疫原
- A synthesized peptide derived from human RFX3, corresponding to a region within C-terminal amino acids.
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                                            亚型
- IgG
 
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                                            应用备注
- WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 
                                            限制
- 仅限研究用
 
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    - 
                                            状态
- Liquid
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                                            浓度
- 1 mg/mL
- 
                                            缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- -20 °C
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                                            储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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                                            有效期
- 12 months
 
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    - RFX3 (Regulatory Factor X 3 (RFX3))
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                                            别名
- RFX3
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                                            背景
- 
                        Description: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). Gene: RFX3 
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                                            分子量
- 84kDa
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                                            基因ID
- 5991
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                                            UniProt
- P48380
 抗原
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