RBM4 抗体 (Internal Region)
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北京 101111
Quick Overview for RBM4 抗体 (Internal Region) (ABIN6264671)
抗原
See all RBM4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- RBM4 Antibody detects endogenous levels of total RBM4.
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预测反应
- Pig,Bovine,Horse,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human RBM4, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-RNA Binding Motif Protein 4 (RBM4) (AA 121-205) antibody
RBM4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 4 (RBM4) antibodyRBM4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 4 (RBM4) (AA 177-207) antibodyRBM4 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 4 (RBM4) (AA 152-201) antibodyRBM4 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 4 (RBM4) (Middle Region) antibodyRBM4 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, Cow, 犬, 山羊 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- RBM4 (RNA Binding Motif Protein 4 (RBM4))
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别名
- RBM4
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背景
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Description: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
Gene: RBM4
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分子量
- 40 kDa
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基因ID
- 5936
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UniProt
- Q9BWF3
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途径
- Regulation of Muscle Cell Differentiation, Photoperiodism
抗原
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