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RAN 抗体 (C-Term)

Name: RAN 抗体 (C-Term)
SKU: ABIN6264629
Availability: OutOfStock

This anti-RAN antibody is a 兔多克隆 antibody detecting RAN in WB, ELISA, IHC, IF 和 ICC. Suitable for 人, 小鼠和大鼠.

IF/ICC

2 images

产品编号 ABIN6264629

发货至: 中国

Quick Overview for RAN 抗体 (C-Term) (ABIN6264629)

抗原

See all RAN 抗体

RAN (RAN, Member RAS Oncogene Family (RAN))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This RAN antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

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C-Term

特异性

RAN Antibody detects endogenous levels of total RAN.

预测反应

Pig,Zebrafish,Bovine,Sheep,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human RAN, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibody
RAN 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8D1A6 unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (N-Term) antibody
Verified RAN 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 2-216) antibody
RAN 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 12-39) antibody
RAN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-179) antibody
RAN 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibody
RAN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 12-39), (N-Term) antibody
RAN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20229 unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 112-140) antibody
RAN 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 197-210) antibody
Verified RAN 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-RAN, Member RAS Oncogene Family (RAN) (AA 1-216) antibody
RAN 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

RAN (RAN, Member RAS Oncogene Family (RAN))

别名

RAN

背景

Description: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).
Gene: RAN

分子量

26 kDa

基因ID

5901

UniProt

P62826

途径

Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus