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RAB5 抗体 (C-Term)

This anti-RAB5 antibody is a 兔 多克隆 antibody detecting RAB5 in WB, ELISA 和 IHC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6264584
发货至: 中国

Quick Overview for RAB5 抗体 (C-Term) (ABIN6264584)

抗原

See all RAB5 (RAB5A) 抗体
RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

适用

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人, 小鼠, 大鼠

宿主

  • 99
  • 11
  • 3
  • 2

克隆类型

  • 91
  • 24
多克隆

标记

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This RAB5 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

    • 18
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    • 1
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    C-Term

    特异性

    Rab5A Antibody detects endogenous levels of total Rab5A.

    预测反应

    Bovine,Horse,Rabbit,Dog,Chicken

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human Rab5A, corresponding to a region within C-terminal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

    别名

    RAB5A

    背景

    Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).

    Gene: RAB5A

    分子量

    24kDa

    基因ID

    5868

    UniProt

    P20339

    途径

    Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
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