SLC26A5 抗体 (Internal Region)
Quick Overview for SLC26A5 抗体 (Internal Region) (ABIN6264415)
抗原
See all SLC26A5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- Prestin Antibody detects endogenous levels of total Prestin.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human Prestin, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) antibody
SLC26A5 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 645-742) antibodySLC26A5 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1F4 unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (AA 351-400) antibodySLC26A5 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) (Middle Region) antibodySLC26A5 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) antibodySLC26A5 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) antibodySLC26A5 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- SLC26A5 (Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5))
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别名
- SLC26A5
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背景
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Description: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
Gene: SLC26A5
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分子量
- 81 kDa
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基因ID
- 375611
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UniProt
- P58743
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途径
- Sensory Perception of Sound, Dicarboxylic Acid Transport
抗原
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