POT1 抗体 (N-Term)
Quick Overview for POT1 抗体 (N-Term) (ABIN6264357)
抗原
See all POT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- POT1 Antibody detects endogenous levels of total POT1.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human POT1, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Protection of Telomeres 1 (POT1) (AA 250-432) antibody
POT1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protection of Telomeres 1 (POT1) (AA 1-95) antibodyPOT1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protection of Telomeres 1 (POT1) (AA 497-634) antibodyPOT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protection of Telomeres 1 (POT1) (AA 251-300) antibodyPOT1 适用: 人, 小鼠, 豚鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Protection of Telomeres 1 (POT1) (Internal Region) antibodyPOT1 适用: 人, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protection of Telomeres 1 (POT1) (AA 251-300) antibodyPOT1 适用: 人, 豚鼠, 犬, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Protection of Telomeres 1 (POT1) (Middle Region) antibodyPOT1 适用: 人, 小鼠, 大鼠, 豚鼠, 犬, 马, Cow, Pig, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- POT1 (Protection of Telomeres 1 (POT1))
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别名
- POT1
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背景
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Description: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
Gene: POT1
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分子量
- 71 kDa
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基因ID
- 25913
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UniProt
- Q9NUX5
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途径
- Cell Division Cycle, Telomere Maintenance
抗原
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