PNPT1 抗体 (C-Term)
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Quick Overview for PNPT1 抗体 (C-Term) (ABIN6264324)
抗原
See all PNPT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- PNPase Antibody detects endogenous levels of total PNPase.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PNPase, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (AA 1-783) antibody
PNPT1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (AA 489-538) antibodyPNPT1 适用: 人, 大鼠, 犬, 马, Cow, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (AA 1-783) antibodyPNPT1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) antibodyPNPT1 适用: 人 WB, IHC (p), IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (N-Term) antibodyPNPT1 适用: 人 WB, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (Middle Region) antibodyPNPT1 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) antibodyPNPT1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (AA 551-650) antibodyPNPT1 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (C-Term) antibodyPNPT1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) (C-Term) antibodyPNPT1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PNPT1 (Polyribonucleotide Nucleotidyltransferase 1 (PNPT1))
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别名
- PNPT1
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背景
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Description: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration, regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity, degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells, specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
Gene: PNPT1
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分子量
- 85kDa
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基因ID
- 87178
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UniProt
- Q8TCS8
抗原
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