PIM2 抗体 (N-Term)
Quick Overview for PIM2 抗体 (N-Term) (ABIN6264221)
抗原
See all PIM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- PIM2 Antibody detects endogenous levels of total PIM2.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PIM2, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibody
PIM2 适用: 人 WB, IHC, IP, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 9A5 unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (AA 277-308), (C-Term) antibodyPIM2 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal RB01288 unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (AA 1-210) antibodyPIM2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (Center) antibodyPIM2 适用: 人, 小鼠 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (AA 23-36) antibodyVerified PIM2 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (C-Term) antibodyVerified PIM2 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) (AA 1-311) antibodyPIM2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibodyPIM2 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibodyPIM2 适用: 人 WB, IHC, IP, IF, FACS 宿主: 小鼠 Monoclonal 8H10 unconjugated
anti-Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) antibodyPIM2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))
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别名
- PIM2
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背景
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Description: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade, this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Gene: PIM2
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分子量
- 34 kDa
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基因ID
- 11040
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UniProt
- Q9P1W9
抗原
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