PIF1 抗体 (Internal Region)
Quick Overview for PIF1 抗体 (Internal Region) (ABIN6264201)
抗原
See all PIF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- PIF1 Antibody detects endogenous levels of total PIF1.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PIF1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-PIF1 5'-To-3' DNA Helicase (PIF1) (AA 125-360) antibody
PIF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PIF1 5'-To-3' DNA Helicase (PIF1) antibodyPIF1 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PIF1 (PIF1 5'-To-3' DNA Helicase (PIF1))
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别名
- PIF1
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背景
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Description: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
Gene: PIF1
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分子量
- 70 kDa
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基因ID
- 80119
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UniProt
- Q9H611
抗原
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