PIAS3 抗体 (N-Term)
Quick Overview for PIAS3 抗体 (N-Term) (ABIN6264198)
抗原
See all PIAS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- PIAS3 Antibody detects endogenous levels of total PIAS3.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PIAS3, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 453-550) antibody
PIAS3 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 4F12 unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 452-628) antibodyPIAS3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (N-Term) antibodyPIAS3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 399-628) antibodyPIAS3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (N-Term) antibodyPIAS3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 548-597) antibodyPIAS3 适用: 人, 大鼠, 犬, Cow, Pig, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 95-126), (N-Term) antibodyPIAS3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0671 unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 588-619) antibodyPIAS3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0673 unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (C-Term) antibodyPIAS3 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 453-550) antibodyPIAS3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PIAS3 (Protein Inhibitor of Activated STAT, 3 (PIAS3))
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别名
- PIAS3
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背景
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Description: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Gene: PIAS3
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分子量
- 68kDa
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基因ID
- 10401
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UniProt
- Q9Y6X2
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途径
- JAK/STAT Signaling
抗原
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