PHF1 抗体 (Internal Region)
Quick Overview for PHF1 抗体 (Internal Region) (ABIN6264170)
抗原
See all PHF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- PHF1 Antibody detects endogenous levels of total PHF1.
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预测反应
- Pig,Horse,Sheep,Rabbit
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PHF1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibody
PHF1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G7 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 151-360) antibodyPHF1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibodyPHF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F5 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibodyPHF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D3 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 1-567) antibodyPHF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 421-470) antibodyPHF1 适用: 人, 大鼠, 犬, 兔, 豚鼠, Bat, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 164-197), (N-Term) antibodyPHF1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB48341 unconjugated
anti-PHD Finger Protein 1 (PHF1) (AA 2-100) antibodyPHF1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (C-Term) antibodyPHF1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, Bat, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-PHD Finger Protein 1 (PHF1) (N-Term) antibodyPHF1 适用: 人, 犬, 兔, Cow, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PHF1 (PHD Finger Protein 1 (PHF1))
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别名
- PHF1
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背景
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Description: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
Gene: PHF1
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分子量
- 62kDa
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基因ID
- 5252
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UniProt
- O43189
抗原
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